Women who enter menopause earlier than age 40 are 35% extra prone to develop dementia, according to a new report. This discovering is of particular curiosity to ladies with diabetes as a result of diabetes is linked to an elevated danger of each premature menopause and dementia. The examine, which was performed by researchers based mostly at Shandong University in Jinan, China, was introduced on the American Heart Association’s Epidemiology, Prevention, Lifestyle & Cardiometabolic Health Conference 2022 in Chicago.
The researchers used statistics from the UK Biobank study, an intensive biomedical database containing genetic and well being info on half one million individuals within the United Kingdom. They retrieved information for 153,291 ladies who have been at a median age of 60 after they started collaborating within the Biobank mission between 2006 and 2010. The researchers recognized ladies who had been recognized with all forms of dementia, whether or not Alzheimer’s disease, vascular dementia (dementia that outcomes from a stroke), and dementia brought on by different elements. They adjusted for doable complicating elements, together with age, academic stage, earnings, bodily exercise, race, body-mass index (BMI), smoking, alcohol use, heart problems, and diabetes. Finally, they decided the age at which the ladies had entered menopause, whether or not it was on the common age of 50-51, untimely menopause (earlier than age 40), and early menopause (earlier than age 45).
Premature menopause linked to elevated dementia danger
The researchers concluded that, in comparison with ladies who expertise menopause after age 50, ladies who start menopause earlier than the age of 40 (untimely menopause) are 35 % extra prone to develop some type of dementia of their later years. Women who expertise early menopause (earlier than age 45) have been 1.3 instances extra prone to undergo dementia. As for girls who expertise menopause on the common age of 50-51, they have been no extra prone to develop menopause than ladies whose menopause started after age 52. Interestingly, though ladies are at a higher danger of stroke after menopause then earlier than it, the researchers didn’t discover any relationship between age at menopause and the chance of vascular dementia.
What would possibly lie behind this relationship between early menopause and dementia danger? Because a lady’s estrogen ranges decline after she enters menopause, lead writer Wenting Hao, MD, speculated that it might need one thing to do with estrogen ranges and oxidative stress (oxidative stress is the results of an imbalance between free radicals and antioxidants within the physique and has been implicated in circumstances similar to persistent irritation, Alzheimer’s illness, cardiovascular issues, and even diabetes). “We know,” she stated, “that the lack of estrogen over the long term enhances oxidative stress, which may increase brain aging and lead to cognitive impairment.”
Quite a lot of analysis must be accomplished earlier than medical consultants advise estrogen remedy for girls to stop dementia. Once it was thought that hormone alternative remedy (HRT) may be sort of a magic bullet for circumstances that accompany growing older, particularly in ladies, however subsequent analysis confirmed that estrogen raised the chance of blood clots and strokes whereas not decreasing the chance of coronary heart assault, and now clinicians are far more hesitant to advocate it. There are, nevertheless, different methods to decrease the percentages of growing dementia. According to Dr. Hao, “Dementia can be prevented, and there are a number of ways women who experience early menopause may be able to reduce their risk of dementia. This includes routine exercise, participation in leisure and educational activities, not smoking and not drinking alcohol, maintaining a healthy weight, getting enough vitamin D, and, if recommended by their physician, possibly taking calcium supplements.”
Want to study extra about sustaining cognitive well being with diabetes? Read “Nine Tips to Keep Your Memory With Diabetes,” “Keeping Your Brain Strong With Diabetes” and “Memory Fitness: How to Get It, How to Keep It.”